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Reduction in meat toughness: regulation of calpastatin by the calcineurin pathway
Reference
D13979
Principal Investigator / Supervisor
Dr Ronald Bardsley
Co-Investigators /
Co-Supervisors
Professor Peter Buttery
,
Dr Paul Sensky
Institution
University of Nottingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
399,996
Status
Completed
Type
Research Grant
Start date
01/12/2000
End date
31/10/2004
Duration
47 months
Abstract
Postmortem proteolysis in muscle is essential for meat tenderisation and quality. Calpain proteinases are proven factors, but their inhibitor is in fact more directly correlated to ultimate tenderness. Calpastatin gene expression yields many alternatively-spliced transcripts, which may not all be translated into functional protein. Specific transcripts and isoform(s) causing meat toughness need to be established in livestock. Differential calpastin isoform expression is affected by both beta adrenergic and IGF-1-mediated pathways. We wish to test a novel hypothesis that muscle growth stimulation in pigs via IGF-1 and calcineurin alters specific calpastatin isoform expression and therefore meat quality.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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