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Mechanisms of transcriptional regulation of lipoprotein secretion by dietary fat

Reference	D11993
Principal Investigator / Supervisor	Dr Michael Billett
Co-Investigators / Co-Supervisors	Dr Andrew Bennett, Professor Andrew Salter, Dr David White
Institution	University of Nottingham
Department	Sch of Biomedical Sciences
Funding type	Research
Value (£)	200,225
Status	Completed
Type	Research Grant
Start date	01/02/2000
End date	01/02/2003
Duration	36 months

Abstract

Amount and fatty acid composition of dietary fat can influence plasma cholesterol levels, partly via effects on hepatic lipoprotein secretion. Our hypothesis is that dietary fats alter hepatic concentrations of specific fatty acyl CoAs which act as agonistic or antagonistic ligands for nuclear receptors. These factors influence transcription of key genes determining the assembly and secretion of lipoproteins. Nutritional, biochemical and molecular genetic approaches will determine the effects of feeding different fats on expression of apoB, MTP, apoA1 and ACAT genes in vivo, and in isolated hepatocytes after manipulation of gene promoters and transcription factor levels, thus elucidating molecular mechanisms of such diet-gene interactions.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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