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Dietary regulation of intestinal zinc transporters

Reference	D11912
Principal Investigator / Supervisor	Professor Dianne Ford
Co-Investigators / Co-Supervisors	Professor Frederick Campbell, Professor John Mathers
Institution	Newcastle University
Department	Agriculture Food and Rural Development
Funding type	Research
Value (£)	195,944
Status	Completed
Type	Research Grant
Start date	01/04/2000
End date	01/04/2003
Duration	36 months

Abstract

The aim of this project is to understand how dietary zinc supply and tissue zinc demand regulate intestinal expression of zinc transporters. Related health issues include reported links, even in Western cultures, between reduced maternal zinc status and low infant birthweight, pertinent in light of the current debate concerning links between low birthweight and cardiovascular disease in later life. We aim to examine regulation of the intestinal zinc transporters ZnT1 and ZnT2, plus a putative model zinc transporter, ZnT5, identified by us. Pregnant and non-pregnant mice will be maintained on diets providing different levels of zinc and phytate. Zinc supplements will be administered to human volunteers. Levels of transporter expression will be quantified by RT-PCR and western blotting. Parallel studies in Caco-2 cells will indicate functional consequences of any observed regulatory responses.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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