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PPARa mediated hypolipidaemia induced by dietary lipids: the guinea pig as a model species

Reference	D11591
Principal Investigator / Supervisor	Dr David Bell
Co-Investigators / Co-Supervisors	Professor Andrew Salter
Institution	University of Nottingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	207,744
Status	Completed
Type	Research Grant
Start date	01/10/1999
End date	01/04/2003
Duration	42 months

Abstract

Dietary lipids induce hypolipidaemia in humans, mediated in part through activation of PPARa, a nuclear receptor which is activated by lipids. The level of PPARa in human liver is very low, and is unable to mediate induction through conventional response elements. We have shown that the guinea pig has a functional PPARa present at low level in liver, which is unable to mediate induction of peroxisome proliferation, but that the guinea pig undergoes PPARa- mediated hypolipidaemia. The guinea pig is an excellent model to investigate the mechanism of PPARa-mediated hypolipidaemia in the human. The project will clarify the site of expression of PPARa and a putative N-terminal splice variant, examine the effect of dietary lipid on genes which may mediate hypolipidaemia, and undertake molecular analysis of the mechanism of gene induction/suppression during hypolipidaemia.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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