Award details

The role of endotoxin (lipid A) in host-pathogen interactions in salmonella infections of mice

Reference	D09661
Principal Investigator / Supervisor	Professor Ian Charles
Co-Investigators / Co-Supervisors
Institution	University College London
Department	Medicine
Funding type	Research
Value (£)	184,892
Status	Completed
Type	Research Grant
Start date	28/11/1998
End date	28/11/2001
Duration	36 months

Abstract

We propose to study early molecular events leading to inflammation, focal lesion development and induction of protective immunity in Salmonella infections in mice. From very early, pre-immune stages of infection, through to host death or the induction of protective responses, bacterial components signal to host cells. We intend to concentrate on the role of lipid A in these events. To this end we have generated mutant salmonellae with defined alterations in lipid A structure and function. Using molecular biology and immunohistochemistry, we have shown that these mutants are profoundly altered in several important host-bacterial interactions, including the local induction within focal lesions of TNF alpha, IL-1 beta and inducible nitric oxide synthase. We plan to extend these studies to understand these events in molecular detail in vivo. This work will generate fundamental knowledge about the infectious disease process and may lead to novel intervention strategies. (Joint with grant D09660).

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

D09660 The role of endotoxin (lipid A) in host-pathogen interactions in Salmonella infections of mice

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