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Regulation of expression of the microsomal triglyceride transfer protein (MTP) gene by dietary fatty acids and cholesterol
Reference
D06478
Principal Investigator / Supervisor
Dr David White
Co-Investigators /
Co-Supervisors
Dr Andrew Bennett
,
Dr Michael Billett
,
Professor Andrew Salter
Institution
University of Nottingham
Department
Sch of Biomedical Sciences
Funding type
Research
Value (£)
248,479
Status
Completed
Type
Research Grant
Start date
01/10/1996
End date
01/03/2000
Duration
41 months
Abstract
Microsomal triglyceride transfer protein (MTP) is required during assembly of very low density lipoprotein in liver and chylomicrons in intestine. Modulation of its activity may influence circulating lipid levels. We wish to study a) the effects of defined dietary fatty acids and cholesterol on intestinal and hepatic MTP expression in hamsters; b) what effect these changes in MTP expression have on synthesis and secretion of apoB containing lipoproteins; c) the mechanisms of these effects by measuring transcription rates and analysing changes in the pattern of proteins bound to the MTP gene promoter in response to diet. This work should produce valuable data to aid in setting nutrition targets to reduce the risk of cardiovascular disease.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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