Award details

Chemo- and stereo-selective benzylic and allylic bacterial enzyme-catalysed oxidations to yield enantiopure alcohols

Reference	CS05324
Principal Investigator / Supervisor	Professor Derek Raymond Boyd
Co-Investigators / Co-Supervisors	Dr Gary Sheldrake
Institution	Queen's University of Belfast
Department	Sch of Chemistry and Chemical Eng
Funding type	Research
Value (£)	172,817
Status	Completed
Type	Research Grant
Start date	01/01/1996
End date	01/01/1999
Duration	36 months

Abstract

The potential of dioxygenase enzyme-catalysed benzylic/allylic oxidation using both whole cell cultures and purified bacterial enzyme systems will be examined as a clean synthetic route to alcohols and ketones. The most efficient bacterial strains from this screening programme and earlier work will be used to produce enantiopure benzylic/allylic alcohol metabolites of either configuration. These will in turn be utilised as intermediates in new synthetic routes to chiral epoxides, ketones and amine derivatives of interest. New chemo-enzymatic routes to arene oxides, trans-dihydrodiols and arene hydrates will be developed from the benzylic/allylic oxidation methodology. (Joint with grant CS05321).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Clean Synthesis - CPD (CS) [1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

CS05321 Chemo- and stereo-selective benzylic and allylic bacteria enzyme-catalysed oxidations to yield enantiopure alcohols

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