Award details

Chemo- and stereo-selective benzylic and allylic bacteria enzyme-catalysed oxidations to yield enantiopure alcohols

Reference	CS05321
Principal Investigator / Supervisor	Professor H Dalton
Co-Investigators / Co-Supervisors
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	101,682
Status	Completed
Type	Research Grant
Start date	04/12/1995
End date	31/05/1999
Duration	42 months

Abstract

The potential of dioxygenase enzyme-catalysed benzylic/allylic oxidation using both whole cell cultures and purified bacterial enzyme systems will be examined as a clean synthetic route to alcohols and ketones. The most efficient bacterial strains from this screening programme and earlier work will be used to produce enantiopure benzylic/allylic alcohol metabolites of either configuration. These will in turn be utilised as intermediates in new synthetic routes to chiral epoxides, ketones and amine derivatives of interest. New chemo-enzymatic routes to arene oxides, trans-dihydrodiols and arene hydrates will be developed from the benzylic/allylic oxidation methodology. (Joint with grant CS05324).

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Clean Synthesis - CPD (CS) [1995]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

CS05324 Chemo- and stereo-selective benzylic and allylic bacterial enzyme-catalysed oxidations to yield enantiopure alcohols

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search