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Genomic approaches to the relationship between hyphal development and protein secretion in the Aspergilli

ReferenceCFB17726
Principal Investigator / Supervisor Professor David Archer
Co-Investigators /
Co-Supervisors
Institution University of Nottingham
DepartmentSch of Biology
Funding typeResearch
Value (£) 186,112
StatusCompleted
TypeResearch Grant
Start date 17/03/2003
End date 16/07/2007
Duration52 months

Abstract

Integrated genomic and proteomic approaches, allied to advanced bioinformatics, will be applied to provide new information on the regulation of hyphal development and protein secretion by filamentous fungi, with a focus on Aspergillus niger. Bottlenecks that limit the application of A. niger as a host for heterologous protein production will be identified in order that they may be overcome. The genome sequence of A. niger has been specifically made available for this project, in which we will grow A. niger under tightly-controlled conditions, develop molecular tools for gene manipulation in Aspergillus species and explore the molecular basis of hyphal development and the stress for protein secretion. (Joint with grant 17723, 17724 and 17725).

Summary

unavailable
Committee Closed Committee - Engineering & Biological Systems (EBS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Cell Function to Bioprocessing (CFB) [2001]
Funding SchemeX – not Funded via a specific Funding Scheme
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