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Genomic approaches to the relationship between hyphal development and protein secretion in the Aspergilli

ReferenceCFB17724
Principal Investigator / Supervisor Professor Stephen Oliver
Co-Investigators /
Co-Supervisors		 Dr Geoffrey Robson
Institution The University of Manchester
DepartmentLife Sciences
Funding typeResearch
Value (£) 571,544
StatusCompleted
TypeResearch Grant
Start date 01/09/2002
End date 30/04/2006
Duration44 months

Abstract

Integrated genomic and proteomic approaches, allied to advanced bioinformatics, will be applied to provide new information on the regulation of hyphal development and protein secretion by filamentous fungi, with a focus on Aspergillus niger. Bottlenecks that limit the application of A. niger as a host for heterologous protein production will be identified in order that they may be overcome. The genome sequence of A. niger has been specifically made available for this project, in which we will grow A. niger under tightly-controlled conditions, develop molecular tools for gene manipulation in Aspergillus species and explore the molecular basis of hyphal development and the stress for protein secretion. (Joint with grant 17723, 17725 and 17726).

Summary

unavailable
Committee Closed Committee - Engineering & Biological Systems (EBS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Cell Function to Bioprocessing (CFB) [2001]
Funding SchemeX – not Funded via a specific Funding Scheme
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