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Metal ion delivery in Synechocystis PCC 6803: chelatase discrimination in the tetrapyrrole pathway

ReferenceC20271/2
Principal Investigator / Supervisor Professor Martin Warren
Co-Investigators /
Co-Supervisors		 Professor Peter Heathcote, Ms Helen Leech, Professor Nigel Robinson, Professor Alison Smith
Institution University of Kent
DepartmentSch of Biosciences
Funding typeResearch
Value (£) 110,087
StatusCompleted
TypeResearch Grant
Start date 01/08/2005
End date 31/12/2006
Duration17 months

Abstract

Cells discriminate between metals to ensure that the correct ions locate to the correct proteins and prosthetic groups but, whilst the mechanisms responsible are fundamental to cellular viability, the actual processes mostly await discovery. By using Synechocystis PCC 6803 as a model system for a study of the relationship between metal requirement and tetrapyrrole biosynthesis, we plan to investigate the in vivo and in vitro activity of the ferrocheletases and cobaltochelatase found in this organism and address the problem of how these enzymes discriminate between divalent metal cations and acquire their metal substrate. In the cases of cobalt we will also study the relationship with metal export and aim to identify tetrapyrrole-derived signalling molecules that help to control and regulate metal homeostasis. (Joint with BBS/B/20090)

Summary

unavailable
Committee Closed Committee - Biochemistry & Cell Biology (BCB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
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