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Molecular and cellular regulation of the system A amino acid transporter in skeletal muscle cells

Reference	C19477
Principal Investigator / Supervisor	Professor Hari Hundal
Co-Investigators / Co-Supervisors	Mr Alexander Hyde, Dr Peter Taylor
Institution	University of Dundee
Department	College of Life Sciences
Funding type	Research
Value (£)	175,072
Status	Completed
Type	Research Grant
Start date	01/04/2003
End date	01/04/2006
Duration	36 months

Abstract

The System A amino acid (AA) transporter is extensively regulated by humoral and nutritional stimuli in skeletal muscle, where it is thought a play a critical role in regulating whole body AA economy. The recent cloning of SAT2, the predominant System A isoform in muscle, has now paved the way for investigating its regulation at the molecular and cellular levels. We aim to apply functional and molecular biological approaches in studies using L6 rat muscle cells, to address (i) the importance of SAT2 for cellular AA nutrition, (ii) mechanisms governing SAT2 surface abundance/activity in response to changes in hormonal/nutritional status and (iii) potential role of SAT2 in cellular AA sensing. The information gained will substantially enhance our understanding of the contribution made by SAT2 to AA turnover in muscle cells, especially with respect to nutritional deprivation and diabetes. This knowledge may prove invaluable for development of new therapeutic strategies aimed at improving whole-body nitrogen balance in catabolic states.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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