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Functional characterisation of ABC50 a novel component of the translational machinery of mammalian cells
Reference
C19142
Principal Investigator / Supervisor
Professor Hari Hundal
Co-Investigators /
Co-Supervisors
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
178,240
Status
Completed
Type
Research Grant
Start date
01/09/2003
End date
30/11/2006
Duration
39 months
Abstract
This proposal focuses on ABC50, an ATP-binding cassette protein which we recently discovered to interact with translation initiation factor eIF2, which is important in controlling protein synthesis. ABC50 stimulates the binding of Met-tRNA to eIF2 and also binds to ribosomes. ABC50 is thus a novel component of the mammalian translational machinery, and this proposal aims to clarify its function in mRNA translation. We will (i) use a range of approaches to explore the role of ABC50 in translation, in particular in events that involve eIF2; (ii) analyse how ABC50 stimulates eIF2 activity; (iii) identify the region of ABC50 that binds eIF2 and (iv) study the role of nucleotide binding/hydrolysis in the function/interactions of ABC50.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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