BBSRC Portfolio Analyser
Award details
Structure and binding specificity of the vesicular trafficking protein SNX1
Reference
C18024
Principal Investigator / Supervisor
Professor Jon Waltho
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
191,928
Status
Completed
Type
Research Grant
Start date
01/03/2003
End date
30/11/2006
Duration
45 months
Abstract
The growth signal following the activation of the EGF receptor is downregulated and switched off through a pathway of intracellular trafficking culminating in EGFR delivery to a lysosome. A key component of that trafficking is the archetypal sorting nexin, SNX1, which distinguishes the delivery target through the specific recognition of PtdIns(3,4,5)P3 using a PX domain. We will investigate the molecular basis of this specificity through the solution structure and dynamics of this unique PX domain, using heteronuclear NMR, in both the presence and absence of ligands. This will be the first structure-based study of any SNX protein (which have widespread roles in trafficking), any dimeric PX domain or any PX protein-protein interactions.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search