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Award details
Roles and mechanisms of action of GPI anchors and N-glycans in cellular targeting and trafficking
Reference
C15608
Principal Investigator / Supervisor
Professor Nigel Hooper
Co-Investigators /
Co-Supervisors
Institution
University of Leeds
Department
Inst of Molecular & Cellular Biology
Funding type
Research
Value (£)
192,876
Status
Completed
Type
Research Grant
Start date
01/01/2002
End date
01/01/2005
Duration
36 months
Abstract
In polarised MDCK epithelial cells the apical targeting of the naturally glycosylated, GPI-anchored dipeptidase is dependent on the presence of the N-glycans, not the GPI anchor. In addition, the GPI anchor appears to act as a forward trafficking signal. The aims of this proposal are to use constructs of dipeptidase to investigate the roles of the GPI anchor, N-glycans and lipid rafts in apical targeting in MDCK cells and other polarised cells, to identify the cellular components interacting with apical targeting signals, to determine the molecular mechanism underlying the GPI anchor acting as a forward trafficking signal, and to characterise the molecular chaperones interacting with dipeptidase in the secretory pathway.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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