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Characterisation of the mode of action of the bacterial toxin Microcin B17 a novel inhibitor of DNA gyrase
Reference
C15130
Principal Investigator / Supervisor
Professor Anthony Maxwell
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
Biological Chemistry
Funding type
Research
Value (£)
169,200
Status
Completed
Type
Research Grant
Start date
30/10/2001
End date
29/10/2004
Duration
36 months
Abstract
Microcin B17 is a bactericidal peptide that targets DNA gyrase. We have shown that microcin induces DNA cleavage by gyrase in the presence of ATP and appears to act by a mechanism distinct from other gyrase inhibitors. Through a series of enzymological studies on gyrase and by the analysis of mutant enzymes and microcin analogues, we aim to obtain a mechanistic understanding of the mode of action of this agent. This work will provide important new knowledge on a novel mode of antibiotic action and further our understanding of the enzymology of gyrase.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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