Award details

Assembly of influenza virus

Reference	C12927
Principal Investigator / Supervisor	Professor Wendy Barclay
Co-Investigators / Co-Supervisors
Institution	University of Reading
Department	Animal and Microbial Sciences
Funding type	Research
Value (£)	172,288
Status	Completed
Type	Research Grant
Start date	31/07/2000
End date	31/07/2003
Duration	36 months

Abstract

Viruses can serve as models for the assembly of complex macromolecular structures incorporating proteins and lipids. The envelopes of influenza viruses have a specific lipid composition which implies they assemble at microdomains within the plasma membrane. The extent of interaction between viral and host gene cell products during this process may influence virion morphology. The project will investigate the role of viral gene products M1, M2 and NB in influenza assembly. The sequences controlling transport of these genes in polarised cells and their distribution into lipid microdomains will be characterised. The effect of mutations on virus assembly will be analysed. Host cell proteins involved in virion assembly, possibly via direct interaction with the viral genes, will be identified.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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