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The dynamics of mitosis the cytoskeleton membrane trafficking and protein expression in microbes and mammalian cells

Reference	C11212
Principal Investigator / Supervisor	Professor Iain Hagan
Co-Investigators / Co-Supervisors	Professor Alan Dickson, Professor Keith Gull, Professor Martin Humphries
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	94,441
Status	Completed
Type	Research Grant
Start date	01/07/1999
End date	01/01/2003
Duration	42 months

Abstract

The generation of autonomously fluorescent proteins by tagging with GFP is having an impact upon the analysis of gene function that parallels the introduction of PCR. Multiple individual proteins can now be simultaneously monitored within the same cell or whole organism. Previously impossible characterisations of the dynamics of many cellular processes will become routine. We will capitalise on this development and use state of the art imaging technology to monitor protein distribution in real time and lapse studies to address fundamental problems of cell biology. Specifically we will study: the formation and function of the mitotic spindle in yeast, mammalian cells and trypanosomes; cell adhesion and stress perception.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	BioImaging (BI) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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