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Regulation of System A amino acid transport by insulin cell stress and microtubular dysfunction
Reference
C10155
Principal Investigator / Supervisor
Professor Hari Hundal
Co-Investigators /
Co-Supervisors
Institution
University of Dundee
Department
College of Life Sciences
Funding type
Research
Value (£)
177,307
Status
Completed
Type
Research Grant
Start date
04/01/1999
End date
04/07/2002
Duration
42 months
Abstract
This application aims to investigate the cellular mechanisms regulating System A amino acid transport by insulin, cellular stress and microtubular dysfunction in skeletal muscle and fat. The work outlined wishes to define in greater detail the role of signalling proteins, in particular that of phosphoinositide 3-kinase, 3-phosphonositide dependant kinase and protein kinase B, and address the potential involvement of intracellular proteins implicated in membrane traffic and fusion in the hormonal and stress-mediated control of System A. These issues will be investigated using numerous techniques including gene and peptide transfection, immunoprecipitation, immunoblotting and functional assays of System A. The results are expected to provide new insights regarding the potential interplay between insulin and stress-activated pathways and their ability to regulate amino acid transport via System A.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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