Award details

Protein transport and membrane trafficking in picornavirus-infected cells

Reference	C07867
Principal Investigator / Supervisor	Professor Martin Ryan
Co-Investigators / Co-Supervisors	Prof. Tom Wileman
Institution	University of St Andrews
Department	University of St Andrews Department
Funding type	Research
Value (£)	154,776
Status	Completed
Type	Research Grant
Start date	01/11/1997
End date	01/11/2000
Duration	36 months

Abstract

A striking characteristic of picornavirus infected cells is the large amount of vesiclulation which occurs. These vesicles are the sites of replication and probably encapsidation of the virus RNA. Recent experiments have shown that inhibition of the formation of ER-derived transport vesicles also strongly inhibits picornavirus replication. In addition membrane transport from the ER to the Golgi is blocked in picornavirus infected cells. We propose that picornavirus-induced vesicles are derived from the ER and that this sequestration of membranes is driven by the interaction of specific virus proteins with host proteins that control membrane trafficking. We wish to investigate which virus protein(s) mediate these effects and determine the site and mechanism of action within the cell.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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