Award details

Alterations in TSE susceptibility defined by specific mutations in PrP

Reference	BS410573
Principal Investigator / Supervisor	Professor Jean Manson
Co-Investigators / Co-Supervisors	Professor David Melton
Institution	The Pirbright Institute
Department	Neuropathogenesis Unit
Funding type	Research
Value (£)	408,364
Status	Completed
Type	Research Grant
Start date	01/04/1999
End date	01/04/2003
Duration	48 months

Abstract

We have produced unique transgenic models for the TSEs by introducing point mutations into the endogenous PrP gene by gene targeting. Mice with four different PrP alleles have been produced (1) 101L (2) 108F189V (3) 108L189V and (4) 108F189T. These mutations are associated with disease susceptibility in human and murine TSEs. We now aim to use these lines of mice to define the mechanism by which the specific mutations in the PrP gene alters the susceptibility of the host to different strains of TSE agent. The control of incubation period of disease by the mutant PrP alleles will be assessed. The extent to which the mutations define the targeting and the severity of the pathological lesions will also be established.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Spongiform Encephalopathies - Phase 4 (BS4) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search