Award details

Molecular characterisation of the pathogenesis of TSE infection

Reference	BS410547
Principal Investigator / Supervisor	Dr Michael Clinton
Co-Investigators / Co-Supervisors	Professor Jean Manson
Institution	The Roslin Institute
Department	Dept of Gene Expression & Bioinformatics
Funding type	Research
Value (£)	163,546
Status	Completed
Type	Research Grant
Start date	01/02/1999
End date	01/02/2002
Duration	36 months

Abstract

In TSEs, the molecular events leading to the resulting neurodegeneration are poorly understood and, at present, there is no effective pre-mortem diagnostic test or therapy for TSE infection. In order to identify early molecular markers of disease and the molecular pathways involved in neurodegeneration following TSE infection, we will characterise the differences in gene expression between infected and non-infected mouse brain with particular emphasis on the early stages of disease. The transcripts identified will be cloned, differential expression confirmed and the expression profiles established by in situ hybridisation. Genes coding for these mRNAs will be isolated, sequenced and characterised and their expression patterns analysed in the blood and peripheral tissues of infected and control mice.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Spongiform Encephalopathies - Phase 4 (BS4) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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