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A study of genes with altered expression in PrP null mice to identify the function of PrP

Reference	BS204795
Principal Investigator / Supervisor	Professor Jean Manson
Co-Investigators / Co-Supervisors	Dr Michael Clinton
Institution	The Pirbright Institute
Department	Neuropathogenesis Unit
Funding type	Research
Value (£)	133,848
Status	Completed
Type	Research Grant
Start date	01/10/1995
End date	01/10/1998
Duration	36 months

Abstract

Mice in which the PrP gene is ablated, develop and behave normally, suggesting other proteins take over the function of PrP in these mice. In order to identify genes coding for these proteins we have carried out a preliminary study to identify mRNAs differentially expressed in PrP null mice compared with wild type mice. This study will be extended to examine all mRNA species expressed at different time points during mouse development. The mRNA species identified will be cloned, sequenced, differential expression confirmed by Northern analysis and the pattern of expression identified by in situ hybridisation. Genes coding for these mRNAs will be isolated, sequenced and characterised.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Biology of Spongiform Encephalopathies - Phase 2 (BS2) [1993]
Funding Scheme	X – not Funded via a specific Funding Scheme

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