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Scrapie strain variation and targeting in transgenic mice with glycosylation deficient PrP
Reference
BS204792
Principal Investigator / Supervisor
Professor Jean Manson
Co-Investigators /
Co-Supervisors
Dr Herbert Baybutt
,
Dr Moira Bruce
Institution
The Pirbright Institute
Department
Neuropathogenesis Unit
Funding type
Research
Value (£)
286,640
Status
Completed
Type
Research Grant
Start date
08/11/1995
End date
08/01/2000
Duration
50 months
Abstract
The hypothesis that strain variation and strain targeting in scrapie are associated with glycosylation patterns of PrP protein will be tested. Transgenic mice with partial or complete absence of N-linked glycosylation in PrP will be produced and injected with specific strains of scrapie. Infected brain material will be subpassaged to establish whether alterations in glycosylation of PrP have affected either disease profile, replication of the agent or strain characteristics on subsequent passage.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Spongiform Encephalopathies - Phase 2 (BS2) [1993]
Funding Scheme
X – not Funded via a specific Funding Scheme
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