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Study of mice with gene-targeted alterations to the PrP gene
Reference
BS204512
Principal Investigator / Supervisor
Professor David Melton
Co-Investigators /
Co-Supervisors
Dr James Hope
,
Professor Jean Manson
Institution
University of Edinburgh
Department
Inst of Cell and Molecular Biology
Funding type
Research
Value (£)
437,661
Status
Completed
Type
Research Grant
Start date
01/06/1995
End date
01/06/1999
Duration
48 months
Abstract
To use gene targeting in embryonic stem cells to produce new mouse strains with specific alterations to their endogenous prion protein (PrP) genes. Mice with PrP mutations found in the Gerstmann-Straussler-Scheinker Syndrome and Creutzfeldt-Jacob Disease will be studied for the development of spontaneous neurodegenerative disease and for susceptibility to scrapie. Mice with PrP codon 108 and 189 changes will be used to resolve the uncertainty over the equivalence of the PrP and scrapie incubation time (Sinc) loci. Mice with truncated forms of PrP will be used to investigate the relationship between PrP protein structure and ability to support replication of the scrapie agent.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biology of Spongiform Encephalopathies - Phase 2 (BS2) [1993]
Funding Scheme
X – not Funded via a specific Funding Scheme
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