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Study of mice with gene-targeted alterations to the PrP gene

ReferenceBS204512
Principal Investigator / Supervisor Professor David Melton
Co-Investigators /
Co-Supervisors
Dr James Hope, Professor Jean Manson
Institution University of Edinburgh
DepartmentInst of Cell and Molecular Biology
Funding typeResearch
Value (£) 437,661
StatusCompleted
TypeResearch Grant
Start date 01/06/1995
End date 01/06/1999
Duration48 months

Abstract

To use gene targeting in embryonic stem cells to produce new mouse strains with specific alterations to their endogenous prion protein (PrP) genes. Mice with PrP mutations found in the Gerstmann-Straussler-Scheinker Syndrome and Creutzfeldt-Jacob Disease will be studied for the development of spontaneous neurodegenerative disease and for susceptibility to scrapie. Mice with PrP codon 108 and 189 changes will be used to resolve the uncertainty over the equivalence of the PrP and scrapie incubation time (Sinc) loci. Mice with truncated forms of PrP will be used to investigate the relationship between PrP protein structure and ability to support replication of the scrapie agent.

Summary

unavailable
Committee Closed Committee - Agri-food (AF)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative Biology of Spongiform Encephalopathies - Phase 2 (BS2) [1993]
Funding SchemeX – not Funded via a specific Funding Scheme
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