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Automated protein structure prediction using templates from the CATH structural database

Reference	BIF08767
Principal Investigator / Supervisor	Professor Christine Orengo
Co-Investigators / Co-Supervisors	Dr Roger Johnson, Dr Nigel John Martin
Institution	University College London
Department	Structural Molecular Biology
Funding type	Research
Value (£)	163,284
Status	Completed
Type	Research Grant
Start date	01/05/1998
End date	30/01/2002
Duration	45 months

Abstract

This project will improve the recognition of protein structures and their possible functions in hitherto uncharacterised sequences. Sequence/structure templates will be derived for families within the CATH database of protein folds and scanned against protein sequences. Emphasis will be put on the use of partial, noisy sequence data, such as from predicted genes and translated ESTs in order to aid the characterisation of new genes. This will involve developing: 1) consensus sequence/structure templates for protein structural families 2) methods for scanning templates against sequence and EST databases to identify relatives 3) techniques for supporting complex schema evolution applied to the CATH database 4) web-based query strategies to access and display data

Summary

unavailable

Committee	Not funded via Committee
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Bioinformatics (BIF) [1995-1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

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