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Platinum anticancer drugs: chemical mechanisms of biotransformations
Reference
BCI06249
Principal Investigator / Supervisor
Professor Peter Sadler
Co-Investigators /
Co-Supervisors
Institution
University of Edinburgh
Department
Sch of Chemistry
Funding type
Research
Value (£)
156,946
Status
Completed
Type
Research Grant
Start date
01/09/1996
End date
01/03/2000
Duration
42 months
Abstract
The anticancer activity and toxic side-effects of platinum complexes depend on the oxidation state of Pt and on the types and numbers of coordinated ligands, and are determined by in vivo biotransformation reactions. Chemical mechanisms of such transformations will be investigated, including (1) pathways of single- and double-stranded DNA platination and HMG recognition, (2) reactivity of adducts with sulphur ligands and (3) activation of Pt (IV) by reductants and light.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Biological Chemistry Initiative (BCI) [1995]
Funding Scheme
X – not Funded via a specific Funding Scheme
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