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Immuno-adsorptive recovery and purification of retroviral agents for gene therapy

ReferenceBCE08049
Principal Investigator / Supervisor Professor Andrew Lyddiatt
Co-Investigators /
Co-Supervisors
Institution University of Birmingham
DepartmentChemical Engineering
Funding typeResearch
Value (£) 79,332
StatusCompleted
TypeResearch Grant
Start date 20/01/1999
End date 20/01/2001
Duration24 months

Abstract

To advance the design and operation of selective adsorptive recovery of retroviral vectors from animal cell cultures, via: (1) The selection of immuno-chemical reagents that selectively interact with virions with association/dissociation constants suited to the adsorptive recovery of vectors from complex feedstocks. (2) The identification of solid phases and associated contactors having sufficient physical capacities and viral accessibility to efficiently accommodate viral particles adsorbed from complex feedstocks. (3) The controlled covalent immobilisation of reagents from (1) to the surface of solid phases from (2) to achieve efficient adsorption and desorption of retroviral agents. (4) The testing of adsorbent assemblies in the recovery of retroviral vectors from realistic production feedstocks in comparison with more conventional adsorptive (e.g. ion exchange and hydrophobic chromatography) and size- based (e.g. density-gradient centrifugation and gel permeation) technologies. (Joint with grants BCE08047 and BCE08048).

Summary

unavailable
Committee Closed Committee - Engineering & Biological Systems (EBS)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative LINK: Biochemical Engineering (BCE) [1993-1997]
Funding SchemeX – not Funded via a specific Funding Scheme
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