Award details

Nucleolar trafficking of a key herpesvirus protein

Reference	BBS/B/03475
Principal Investigator / Supervisor	Professor Adrian Whitehouse
Co-Investigators / Co-Supervisors	Professor Julian Hiscox
Institution	University of Leeds
Department	Inst of Molecular & Cellular Biology
Funding type	Research
Value (£)	172,918
Status	Completed
Type	Research Grant
Start date	28/06/2004
End date	27/06/2007
Duration	36 months

Abstract

Many viral proteins shuttle to the nucleolus. The role of these nucleolar interactions have not been determined. We have shown that a herpesvirus protein, ORF 57, trafficks and redistributes cellular proteins into the nucleolus. We aim to use this protein to investigate the role of virus-nucleolar interactions. We will determine how ORF 57 trafficks to the nucleolus and analyse its effect on nucleolar architecture. Proteomic analysis of the nucleolus will identify cellular proteins redistributed by ORF 57. Identified proteins involved in RNA metabolism will be characterised for their nucleolar localisation and interaction with ORF 57. RNAi studies will be performed to assess their effect on ORF 57-mediated viral mRNA nuclear export.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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