Award details

Nucleolar localisation of the coronavirus nucleoprotein and its role in cell cyle control

Reference	BBS/B/03416
Principal Investigator / Supervisor	Professor Julian Hiscox
Co-Investigators / Co-Supervisors	Professor Gavin Brooks
Institution	University of Leeds
Department	Inst of Molecular & Cellular Biology
Funding type	Research
Value (£)	188,493
Status	Completed
Type	Research Grant
Start date	01/04/2004
End date	31/03/2007
Duration	36 months

Abstract

The nucleolus is a dynamic sub-nuclear structure involved in cell cycle regulation. This proposal will investigate the relationship between nucleolar shuttling and cell cycle regulation using the avian coronavirus nucleoprotein as a model protein. We have previously shown that nucleoprotein localises to the nucleolus and disrupts the cell cycle. Our hypothesis is that nucleoprotein localises to the nucleolus to alter the cell cycle in order to promote conditions for virus replication. To investigate this, we propose to determine when in the cell cycle nucleoprotein localises to the nucleolus, how nucleolar shuttling affects the cell cycle and determine how the cell cycle affects the virus replication.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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