Award details

Nucleolar localisation of the coronavirus nucleoprotein and its role in cell cyle control

Principal Investigator / Supervisor Professor Julian Hiscox
Co-Investigators /
Professor Gavin Brooks
Institution University of Leeds
DepartmentInst of Molecular & Cellular Biology
Funding typeResearch
Value (£) 188,493
TypeResearch Grant
Start date 01/04/2004
End date 31/03/2007
Duration36 months


The nucleolus is a dynamic sub-nuclear structure involved in cell cycle regulation. This proposal will investigate the relationship between nucleolar shuttling and cell cycle regulation using the avian coronavirus nucleoprotein as a model protein. We have previously shown that nucleoprotein localises to the nucleolus and disrupts the cell cycle. Our hypothesis is that nucleoprotein localises to the nucleolus to alter the cell cycle in order to promote conditions for virus replication. To investigate this, we propose to determine when in the cell cycle nucleoprotein localises to the nucleolus, how nucleolar shuttling affects the cell cycle and determine how the cell cycle affects the virus replication.


Committee Closed Committee - Biochemistry & Cell Biology (BCB)
Research TopicsX – not assigned to a current Research Topic
Research PriorityX – Research Priority information not available
Research Initiative X - not in an Initiative
Funding SchemeX – not Funded via a specific Funding Scheme
terms and conditions of use (opens in new window)
export PDF file