Award details

Basis for epithelial barrier variation

Reference	BBS/X/00018
Principal Investigator / Supervisor	Professor Carolyn Ruth Byrne
Co-Investigators / Co-Supervisors
Institution	Queen Mary University of London
Department	Barts and The London School of Medicine
Funding type	Research
Value (£)	37,151
Status	Completed
Type	Research Grant
Start date	14/07/2003
End date	13/02/2004
Duration	7 months

Abstract

Animals form epithelial barriers at environmental interfaces (skin, oral epithelia), providing protection from microbial entry and water loss. However barrier properties (conferred by stratum corneum) differ dramatically at different body locations. This group has identified proteins that are differentially expressed in stratum corneum-forming cells at specific body locations. It is proposed that these proteins are new stratum corneum precursors and that they confer distinct barrier properties. The aim is to test this hypothesis by showing that the proteins are stratum corneum components and altering expression patterns to test for altered barrier properties. The outcome will be an understanding of the molecular basis for barrier function.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

S13352 Basis for epithelial barrier variation

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