Award details

Basis for epithelial barrier variation

Reference	S13352
Principal Investigator / Supervisor	Professor Carolyn Ruth Byrne
Co-Investigators / Co-Supervisors
Institution	The University of Manchester
Department	Life Sciences
Funding type	Research
Value (£)	211,772
Status	Completed
Type	Research Grant
Start date	01/11/2000
End date	30/04/2003
Duration	30 months

Abstract

Animals form epithelial barriers at environmental interfaces (skin, oral epithelia), providing protection from microbial entry and water loss. However barrier properties (conferred by stratum corneum) differ dramatically at different body locations. This group has identified proteins that are differentially expressed in stratum corneum-forming cells at specific body locations. It is proposed that these proteins are new stratum corneum precursors and that they confer distinct barrier properties. The aim is to test this hypothesis by showing that the proteins are stratum corneum components and altering expression patterns to test for altered barrier properties. The outcome will be an understanding of the molecular basis for barrier function.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

BBS/X/00018 Basis for epithelial barrier variation

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