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Energy coupling in type II topoisomerases: why do they hydrolyse ATP?
Reference
BBS/E/J/0000A224
Principal Investigator / Supervisor
Professor Anthony Maxwell
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
John Innes Centre Department
Funding type
Research
Value (£)
172,630
Status
Completed
Type
Institute Project
Start date
15/11/2005
End date
31/03/2009
Duration
41 months
Abstract
Energy coupling in type II topoisomerases: why do they hydrolyse ATP? DNA topoisomerases catalyse the interconversion of different topological forms of DNA and have essential roles in replication and transcription. They are of two types, I and II, depending on whether they catalyse reactions involving single- or double-strand DNA breaks. All type II topoisomerases hydrolyse ATP, although many of their reactions are not energy-requiring. The goal of this work is to investigate energy coupling aspects of type II enzymes and establish the role of ATP hydrolysis in their reactions.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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