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Streptomyces coelicolor as a model for the end-user driven exploitation of a genome sequence
Reference
BBS/E/J/0000A106
Principal Investigator / Supervisor
Professor Mark Buttner
Co-Investigators /
Co-Supervisors
Dr Robert Sawers
Institution
John Innes Centre
Department
John Innes Centre Department
Funding type
Research
Value (£)
192,984
Status
Completed
Type
Institute Project
Start date
01/10/2002
End date
31/01/2007
Duration
52 months
Abstract
The objectives of this proposal are to exploit two recent major technical breakthroughs, efficient in vivo transposition and rapid PCR-directed gene disruption, to begin to construct a comprehensive, defined knockout library for all non- essential genes in S. coelicolor, and to apply the new technologies to (i) explore the secondary metabolic potential of the genome (ii) analyse gene expression and metabolism under oxygen limitation (iii) define all the genes required for morphological differentiation, and (iv) characterise the Tat secretion pathway.
Summary
unavailable
Committee
Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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