Award details

Characterisation of the mode of action of the bacterial toxin microcin B17, a novel inhibitor of DNA gyrase

Reference	BBS/E/J/0000A004
Principal Investigator / Supervisor	Professor Anthony Maxwell
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	41,764
Status	Completed
Type	Institute Project
Start date	30/10/2001
End date	30/10/2004
Duration	36 months

Abstract

Microcin B17 is a bactericidal peptide that targets DNA gyrase. We have shown that microcin induces DNA cleavage by gyrase in the presence of ATP and appears to act by a mechanism distinct from any other gyrase inhibitor. Through a series of enzymological studies on gyrase and by the analysis of mutant enzymes and microcin analogues, we aim to obtain a mechanistic understanding of the mode of action of this agent. This work will provide information on a novel mode of antibiotic action and further our understanding of the enzymology of gyrase.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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