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Genetic characterisation of new sporulation genes in Streptomyces coelicolor A3(2)

Reference	BBS/E/J/00004022
Principal Investigator / Supervisor	Professor Mark Buttner
Co-Investigators / Co-Supervisors
Institution	John Innes Centre
Department	John Innes Centre Department
Funding type	Research
Value (£)	1,174
Status	Completed
Type	Institute Project
Start date	01/10/1997
End date	10/05/2001
Duration	43 months

Abstract

It is clear from recent analysis that there are many mutations that block development of S. coelicolor after sporulation septum formation, or cause aberrant placement of the septum, which do not correspond to known sporulation (whi) loci. The aim of this work is to define, map and clone new whi loci which, in genetic terms, bridge the gap in the developmental pathway between the early stages of sporulation, as represented by the whiA, whiB, whiG, whiH, whiI and whiJ loci, and the late stages of sporulation, as represented by sigF. The work will take advantage of the technological advances made possible by the recent construction of an ordered cosmid library for S. coelicolor, which will allow this important target to be achieved with a relatively small investment of resources.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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