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The interaction of DNA gyrase with FdhE, a protein involved in the assembly of the formate dehydrogenase complex
Reference
BBS/E/J/00004019
Principal Investigator / Supervisor
Professor Anthony Maxwell
Co-Investigators /
Co-Supervisors
Institution
John Innes Centre
Department
John Innes Centre Department
Funding type
Research
Value (£)
44,597
Status
Completed
Type
Institute Project
Start date
01/03/1999
End date
31/05/2002
Duration
39 months
Abstract
DNA gyrase is a type II topoisomerase from bacteria which controls the level of DNA supercoiling. Using affinity columns we have found evidence for specific interaction between the gyrase A subunit and FdhE, a protein involved in the assembly of the formate dehydrogenase complex in E. coli. Experiments in vitro show that FdhE can inhibit gyrase-catalysed DNA supercoiling and DNA binding. We have now made a fusion construct which expresses FdhE and plan to investigate its potential role in the regulation and control of the physiology and enzymology of DNA gyrase
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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