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Studentship: Interaction between the neurovirulence protein from herpesvirus and the ER-resident TF:structural, biochemical and physiological insights

Reference	BBS/E/I/00001833
Principal Investigator / Supervisor	Professor Venugopal Nair
Co-Investigators / Co-Supervisors	Dr ABDESSAMAD TAHIRI-ALAOUI
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	85,851
Status	Completed
Type	Institute Project
Start date	17/02/2014
End date	31/03/2017
Duration	37 months

Abstract

Marek's disease virus (MDV) is an oncogenic avian herpesvirus that induces malignant T-cell lymphomas and neurological disorders in its natural host, chicken. Although tropism for the central nervous systems is consistently associated with highly virulent MDV strains, the mechanism of MDV-mediated neuropathology is still poorly understood. For the first time, phosphoprotein-14 (pp14), an immediate early protein from MDV1, has been identified as a neurovirulence factor. Furthermore, cAMP Response Element-Binding protein 3 (CREB3) has been identified as a cellular ligand for pp14 through which the viral protein may mediate the neurovirulence. CREB3 is a membrane-bound transcription factor that has recently been shown to be activated in response to DNA and RNA viral infections. Although transcription factors of the CREB3 subfamily are understood to be activated through regulated intra-membrane proteolysis (RIP) the physiological stimuli for proteolytic activation of discrete transcription factors in the CREB3 subfamily and their physiological targets remain to be identified and characterised. The aim of this project is to use a combination of biochemical, reverse genetic and structural approaches to derive new knowledge in pp14-CREB3-mediated neurovirulence.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Microbiology, Neuroscience and Behaviour
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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