Award details

Molecular interactions in oncogenesis by avian oncogenic viruses

Reference	BBS/E/I/00001704
Principal Investigator / Supervisor	Professor Venugopal Nair
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	2,956,832
Status	Completed
Type	Institute Project
Start date	01/04/2012
End date	31/03/2017
Duration	59 months

Abstract

Avian oncogenic viruses such as Marek’s disease virus (MDV), avian leukosis virus (ALV) and reticuloendotheliosis virus (REV) account for significant economic losses to the poultry industry worldwide . These viruses are excellent models for understanding the molecular oncogenic mechanisms of these viruses in disease models in their natural hosts. The project will examine the functions of viral genes and their interactions with host proteins in inducing pathogenesis. The use of reverse genetics systems including the full-length genomic clones of retroviruses and bacterial artificial chromosome (BAC) clones of Marek’s disease viruses will enable the examination of the functional role of viral genes in pathogenesis. In addition, the infectious clones of these viruses will also be used to develop novel recombinant vaccines, the protective efficacy of which will be evaluated in virulent virus infection models. Finally, the evolution of viruses towards increased virulence and the role of vaccines in driving the virulence will also be investigated using a combination of molecular biological studies and natural disease models.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Immunology, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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