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Translational control by non-coding RNA in Marek's disease herpesvirus: implications in oncogenesis and exploitation in bioengineering

Reference	BBS/E/I/00001483
Principal Investigator / Supervisor	Professor Venugopal Nair
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	127,762
Status	Completed
Type	Institute Project
Start date	01/04/2010
End date	31/03/2013
Duration	36 months

Abstract

Studies of virus-infected cells have been a prominent source of information on the mechanism of translational control. Because viruses are obligate intracellular parasites, they depend on cells for their replication. Nowhere is this dependency seen more clearly than in the translation system, as viruses lack a translational apparatus. Consequently, viruses must use the cellular apparatus for the synthesis of viral proteins. Many viruses have evolved ways to gain a translational advantage for their mRNAs. This is particularly crucial during the very early stages of viral infection where immediate-early transcripts are produced and need to be translated. Internal ribosome entry site (IRES)-mediated translation initiation is one of the strategies that viruses use during time of cellular stress and when cap-dependent translation might be inhibited. We have discovered that the protein translation from one of the immediate-early transcripts of MDV (named 1.8kBtranscript) is controlled using two IRES elements and the translational strategy used by MDV in the causation of disease will be the subject of investigation under this project.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	Animal Health, Microbiology
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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