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Award details
Interaction of Marek's disease virus Meq protein and chicken CtBP in cell transformation and the pathogenesis of Marek's disease
Reference
BBS/E/I/00001190
Principal Investigator / Supervisor
Professor Venugopal Nair
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
150,370
Status
Completed
Type
Institute Project
Start date
01/12/2005
End date
31/03/2009
Duration
40 months
Abstract
The objectives are: 1) to determine the molecular details and consequences of the interaction between Marek's disease virus (MDV)-encoded Meq and the cellular co-repressor of transcription CtBP. We will attempt to answer the question - why is CBP necessary for MDV-mediated cell transformation?; 2) to identify the precise stage(s) when this interaction is important in the pathogenesis of Marek's disease; and 3) to determine whether engineered viruses encoding CtBP-binding mutants of Meq would be suitable for the development of a new recombinant vaccine for the prevention of Marek's disease.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
Animal Health, Immunology, Microbiology
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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