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Probing molecular mechamisms of neurodegenerative ageing of prion ablated mice
Reference
BBS/E/I/00001180
Principal Investigator / Supervisor
Dr Andrew Gill
Co-Investigators /
Co-Supervisors
Dr Janet Fraser
,
Professor Jean Manson
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
82,677
Status
Completed
Type
Institute Project
Start date
01/03/2006
End date
28/02/2009
Duration
36 months
Abstract
The objectives are to identify differentially transcribed genes in aged PrP0/0 mice relative to wild-type controls by a microarray approach; to provide complementary information of protein levels in these mice by comparative proteomics techniques; to demonstrate whether ¿down-regulation¿ of particular proteins represents regulation of transcription or loss of specific neurones; to investigate whether transgenic mice expressing mutated PrP proteins show similar molecular and physiological phenotype to PrP0/0 mice on ageing; to build a model of the mechanisms of the neuroprotective mechanisms of PrPc during ageing.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
Ageing, Animal Health, Neuroscience and Behaviour, TSEs (transmissible spongiform encephalopathies)
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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