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Marek's disease virus pathogenesis: investigating viral gene expression profiles by transcriptome analysis

Reference	BBS/E/I/00001119
Principal Investigator / Supervisor	Professor Venugopal Nair
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	3,626
Status	Completed
Type	Institute Project
Start date	01/11/2004
End date	31/10/2006
Duration	24 months

Abstract

Marek¿s disease is a highly contagious disease caused by an oncogenic herpesvirus. MDV genome shows more than 100 ORFs. Although most of these genes are homologues of other herpesvirus genes, there are several other genes unique to MDV. The expression kinetics of MDV genes and their association with the unique biological characteristics of MDV-induced disease have not been systematically studied. DNA microarrays have been used as powerful tools for analysing genome-wide expression of several herpesviruses. In order to provide a better understanding of how the temporal pattern ofn MDV gene expression contributes to viral replication and pathogenicity, we propose to investigate the MDV transcription programme using DNA arrays. MDV transcriptome analysis would provide an understanding of the molecular basis for many unique properties of MDV.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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