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Investigation of transmissible spongiform encephalopathies using transgenic models

Reference	BBS/E/I/00000838
Principal Investigator / Supervisor	Professor Jean Manson
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	39,130
Status	Completed
Type	Institute Project
Start date	01/10/2000
End date	30/09/2003
Duration	36 months

Abstract

We have recently developed models of TSE disease in which disease develops rapidly when inoculated with infectivity but only extremely low levels of PrPSc can be detected.The infectivity can be passaged from the brains of these to other mice.These models will be used to examine the nature of the infectious agent in TSE disease. The forms of PrP present in the uninfected and infected animals will be investigated. The PK sensitivity and cellular location of the different forms of PrP will be examined. Fractionation and infectivity studies on the infected brains will establish whether in the absence of PrPSc the infectious agent is associated with PrP.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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