Award details

Immunological tolerance against ALV-J infection in meat-type chickens: Role of novel endogenous retroviral elements

Reference	BBS/E/I/00000823
Principal Investigator / Supervisor	Professor Venugopal Nair
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	108,380
Status	Completed
Type	Institute Project
Start date	01/04/2001
End date	31/03/2004
Duration	36 months

Abstract

Avian leukosis virus subgroup J (ALV-J), first isolated by our group in the late 1980s from the UK, has since spread rapidly world-wide and is one of the major diseases affecting the poultry industry today. In the field the disease associated with ALV-J occurs only in chickens selectively bred for meat production and this was related to the specific immunological tolerance of meat-type chickens to ALV-J infection. Although the exact basis for the tolerance is not clear, recently we identified novel endogenous retroviral elements in the chicken genome with 98% homology to the envelope gene of ALV-J. The proposed project is to examine the role of these novel elements in the induction of tolerance against ALV-J in meat-type chickens.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search