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Non-coding elements of the PrP gene and TSE susceptibility

Reference	BBS/E/I/00000814
Principal Investigator / Supervisor	Professor Jean Manson
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	57,330
Status	Completed
Type	Institute Project
Start date	01/04/2000
End date	31/08/2001
Duration	17 months

Abstract

In order to establish if PrP gene expression is involved in TSE susceptibility it is first necessary to determine which sequences in the PrP drive expression of the gene. We are aiming to define these sequences for both mouse and human PrP. The analysis will be carried out both in vitro through the use of reporter gene constructs and in vivo by producing mice transgenic for a reporter gene under control of PrP sequences. This analysis will allow the sequences responsible for temporal and tissue specificity of PrP gene expression to be established Having defined the sequences which drive PrP gene expression, these sequences will be examined for polymorphisms. The level of PrP gene expression associated with polymorphic sequences will be examined to establish if the polymorphic sequences are associated with different expression levels of PrP. In addition a study will be carried out using CJD patients and controls to establish if any polymorphic sequences are associated with TSE disease susceptibility.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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