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Can full length Marek's disease virus genome be constructed as an infectious bacterial artificial chromosome?
Reference
BBS/E/I/00000713
Principal Investigator / Supervisor
Professor Venugopal Nair
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
The Pirbright Institute Department
Funding type
Research
Value (£)
40,460
Status
Completed
Type
Institute Project
Start date
22/03/1999
End date
21/09/2000
Duration
18 months
Abstract
Marek's disease (MD) is a naturally occurring neoplastic disease of poultry caused by a highly oncogenic herpesvirus. Conventional mutational approaches of MDV genome to study the viral gene functions have proven to be extremely difficult. The project aims to develop a novel strategy for cloning the MDV genome in a single step as an infectious bacterial artificial chromosome in E. coli. If successful, this method would provide a stable infectious clone of the MDV generating virus stocks with uniform characteristics. This will also help in the manipulation the whole genome as a single entity in E. coli independent of the biological fitness of the mutant virus.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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