Award details

Molecular basis and characterisation of oncogenesis and genetic susceptibility to myeloid leukosis induced by subgroup J avian leukosis virus

Reference	BBS/E/I/00000710
Principal Investigator / Supervisor	Professor Venugopal Nair
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	14,339
Status	Completed
Type	Institute Project
Start date	01/02/1998
End date	31/01/2001
Duration	36 months

Abstract

The Project involves the studies on the myeloid leukaemogenicity of avian leukosis virus subgroup J (ALV-J). This new virus causes serious losses from myeloid tumours in commercial meat-type breeding lines. The project aims to investigate the molecular epidemiology of the disease, antigenic variation among ALV-J, the pattern of inheritance of genetic resistance among different inbred and commercial lines of chickens and try to understand the molecular basis of oncogenicity and genetic susceptibility to ML induced by ALV-J. Studies will include in vitro transformation assays of cells using acute transforming variants of ALV-J as an alternative to the in vivo oncogenicity tests in birds. The results could provide a simple and rapid means of identifying resistant birds and a basis for selection of genetically resistant commercial stock.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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