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Molecular characterisation of the pathogenesis of TSE infections

Reference	BBS/E/I/00000683
Principal Investigator / Supervisor	Professor Jean Manson
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	2,810
Status	Completed
Type	Institute Project
Start date	01/02/1999
End date	01/02/2002
Duration	36 months

Abstract

In TSEs, the molecular events leading to the resulting neurodegeneration are poorly understood and, at present there is no effective pre-mortem diagnostic test or therapy for TS infection. In order to identify early molecular markers of disease and the molecular pathways involved in neurodegeneration following infection, we will characterise the differences in gene expression between infected and non- infected mouse brain with particular emphasis on the early stages of disease. The transcripts identified will be cloned, differential expression confirmed and expression profiles established by in situ hybridisation. Genes coding for these mRNAs will be isolated, sequenced and characterised and their expression patterns analysed in the blood and peripheral tissues of infected and control mice.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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