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Alteration of TSE susceptibility defined by specific mutations in PrP

Reference	BBS/E/I/00000682
Principal Investigator / Supervisor	Professor Jean Manson
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	The Pirbright Institute Department
Funding type	Research
Value (£)	500,320
Status	Completed
Type	Institute Project
Start date	01/04/1999
End date	01/04/2003
Duration	48 months

Abstract

We have produced unique transgenic models for the TSEs by introducing point mutations into the endogenous PrP gene by gene targeting. Mice with four different PrP alleles have been produced (1) 101L (2)108F189V (3) 108L189V and (4) 108F189T. These mutations are associated with disease susceptibility in human and murine TSEs. We now aim to use these lines of mice to define the mechanism by which specific mutations in the PrP gene alters the susceptibility of the host to different strains of TSE agent. The control of incubation period of disease by the mutant PrP alleles will be assessed. The extent to which the mutations define the targeting and severity of the pathological lesions will also be established

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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